Tranexamic Acid

Accelerate your whitening line with our 99% Ultra-Pure Tranexamic Acid, a clinically proven bioactive that targets the root cause of melasma and PIH by inhibiting plasminogen activity. As a COSMOS-certified manufacturer, Shaanxi Huatai Bio offers Cosmetic grade 99% purity, backed by complete technical dossiers (COA/MSDS/TDS) to ensure your brand’s regulatory success in the global market.

1. Product Overview & Key Specifications

Tranexamic Acid is a synthetic raw material that inhibits fibrinolysis by preventing the conversion of plasminogen into plasmin. Its raw material’s half-life is longer, and its efficacy is about ten times that of aminocaproic acid. The ingredient is characterized by low irritation, no irritation for masks, and offers excellent performance when combined with other whitening materials.

2. Technical Highlights & Critical Parameters

2.1 Tranexamic Acid Core Efficacy

• Chloasma (Melasma) Treatment: Clinical studies have shown Tranexamic Acid reduces the severity of chloasma.
• Quick Whitening: Proven to make skin white and bright within 1-2 weeks.
• Spot Prevention: Inhibits melanin synthesis and prevents the appearance of new pigment spots and freckles.
• Anti-Inflammatory Whitening: Blocks the UV-induced keratinocyte PA system, which leads to melanin formation.

2.2 Superior Safety Profile (Tranexamic Acid vs. Hydroquinone)

In a spot removal study comparing Tranexamic Acid versus Hydroquinone + Dexamethasone in the treatment of chloasma:

• Efficacy: Tranexamic Acid had the same cumulative effect as the hydroquinone + dexamethasone group in treating chloasma.
• Safety: Tranexamic Acid was significantly safer.
• Side Effects: The Tranexamic Acid only group reported 20% side effects, compared to 48% in the hydroquinone + dexamethasone group.

3. Mechanism of Action (MoA)

Tranexamic Acid works primarily by interfering with the inflammatory pathways that trigger melanogenesis:

• Plasmin Inhibition: It inhibits the conversion of plasminogen to plasmin.
• Melanogenesis Blockade: The UV-induced keratinocyte PA system is blocked, which otherwise leads to melanin formation and is a key factor in chloasma.
• Reduced Inflammatory Factors: Prevents the release of inflammatory and injury factors (like UV light/inflammation/injury) which stimulate melanocytes via the Plasmin/FGF pathway.

4. Core Advantages & Market USPs

4.1 Competitive Edge for Your Brand

• Clinical Validation: Proven efficacy in reducing the severity of chloasma.
• Safety vs. Gold Standard: Achieves efficacy comparable to hydroquinone + dexamethasone, but with a much lower side effect rate (20% vs. 48%).
• Fast Results: Promotes white and bright skin within 1-2 weeks.
• Stability: Excellent thermal stability and good compatibility with other whitening agents.

5. Formulation Guidelines

• Appearance/Physical State: Easily soluble in water, colorless, odorless.
• Stability Notes: High thermal stability; not easily discolored.
• Irritation: Low irritation profile, making it suitable for facial masks.

6. Quality Assurance & Regulatory Confidence

We are committed to the highest standards of quality and regulatory compliance.

6.1 Certificate Section

Our quality and safety credentials include:

• COSMOS (Natural and Organic Cosmetic Standard)
• ISO 9001 Quality Management System
• ISO 22000 Food Safety Management System
• HALAL Certification
• IQNET (The International Certification Network)
• Technical Dossier (Certificate of Analysis – COA, Technical Data Sheet – TDS, Material Safety Data Sheet – MSDS)

7. Recommended Synergistic Combinations

• Tranexamic Acid + Niacinamide: Combines anti-plasmin action with melanin transfer inhibition.
• Tranexamic Acid + Vitamin C: Enhances overall brightening and antioxidant effects.

8. Typical Applications & Success Stories

• Product Categories: Whitening/Brightening Serums, Anti-Chloasma Treatments, Spot Corrector Fluids, Toner/Essences.

9. Scientific Evidence & Literature Support

9.1 Clinical Spot Removal Test

• Study Aim: To compare the safety and efficacy of 3% Tranexamic Acid local solution with 3% hydroquinone and 0.01% dexamethasone in the treatment of chloasma.
• Results: Tranexamic Acid group showed comparable cumulative effect on Melasma Area and Severity Index (MASI) score reduction over 12 weeks compared to the hydroquinone + dexamethasone group.
  • MASI Score (Baseline to 12 Weeks): Tranexamic Acid reduced MASI from $31.68$ to $12.01$; Combination reduced MASI from 29.52 to 12.37.

• Side Effects: The Tranexamic Acid group reported 20% side effects, while the combination group reported 48% side effects.

10. Stability and Safety Data Summary

• Safety Profile: Much smaller toxicity compared to aminocaproic acid, with a similar mechanism of action.
• Physical Stability: Colorless, odorless, high thermal stability.

11. Frequently Asked Questions

Q1: What is the CAS number for Tranexamic Acid?

A: The CAS number is 1197-18-8.

Q2: Is Tranexamic Acid water-soluble?

A: Yes, it is easily soluble in water.

Q3: How fast can results be seen?

A: It is a quick effect product, making skin white and bright within 1-2 weeks.

Q4: Is Tranexamic Acid safer than Hydroquinone?

A: Clinical results showed Tranexamic Acid had similar efficacy but was safer, reporting 20% side effects versus 48% for the hydroquinone combination.

Source the Clinically Superior Tranexamic Acid for Safe, Fast, and Effective Whitening Formulations.

🔒 Get Your Technical Dossier: Access TDS, MSDS, COA, and Clinical Efficacy Reports.

🔬 Apply for a Free Sample: Test the stable, high-efficacy brightening power of Tranexamic Acid today.

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