Licochalcone A

Shaanxi Huatai Bio-Fine Chemical is a specialized manufacturer of Licochalcone A (CAS No. 58749-22-7), a potent flavonoid isolated from the root of Glycyrrhiza inflata (Licorice).

We provide premium grade Licochalcone A ranging from 70% to 95% purity, which appears as a characteristic brownish yellow powder. Recognized for its exceptional anti-inflammatory and bacteria-inhibiting properties, it is a gold-standard ingredient for formulating products targeting sensitive skin, rosacea, and acne. Unlike generic extracts, our Licochalcone A ensures low solvent residue and high stability, making it ideal for high-end dermo-cosmetic applications.

1. Product Overview & Key Specifications

Licochalcone A is a chalcone-type compound found in the Licorice plant. Our Licochalcone A is predominantly extracted from the Licorice root and stem, as these parts are richer in Licochalcone A than leaves and seeds. Due to its complex structure, it is a high-cost, high-value ingredient. It is an effective solution for reducing the occurrence of inflammatory skin diseases.

2. Technical Highlights & Critical Parameters

We provide the hard data R&D teams need to ensure seamless formulation and superior performance.

2.1 Licochalcone A Core Efficacy

• Anti-Aging & ROS Reduction: Licochalcone A reduces ROS (Reactive Oxygen Species) levels and inhibits telomere shortening, which are primary factors in cellular senescence.
• Anti-Inflammatory Action: LA can inhibit the synthesis of NO (Nitric Oxide) and the expression of iNOS (inducible Nitric Oxide Synthase) and COX-2 (Cyclooxygenase-2). This prevents the release of pro-inflammatory factors and reduces the frequency of inflammatory skin issues.
• Broad Application: Licochalcone A is suitable for combating various skin inflammations, such as pediatric atopic dermatitis and photo-inflammation caused by UV radiation.

2.2 Customizable Grade Options

Storage Condition: Avoid light, ventilation, dry, in a sealed space.

3. Mechanism of Action (MoA)

LA primarily works by downregulating inflammatory pathways and combating oxidative stress at the cellular level. Its mechanism includes:

1. Reducing ROS Levels that lead to cellular senescence.
2. Inhibiting the release of pro-inflammatory factors to prevent skin inflammation.
3. Inhibiting Tyrosinase activity while showing clear inhibition against Staphylococcus aureus.

4. Core Advantages & Market USPs

4.1 Competitive Edge for Your Brand

• Multi-Functional Power: Simultaneously delivers Anti-Aging, Anti-Inflammatory, and Antibacterial benefits.
• Targeted Anti-Aging: Directly targets the root cause of aging by reducing ROS and inhibiting telomere shortening.
• High Purity (up to 95%): Ensures potent efficacy for advanced formulations.
• Natural Anti-Inflammatory: An excellent natural solution for sensitive, reactive, and acne-prone skin.

5. Formulation Guidelines

• Recommended Use Level: 0.1% – 2% across all grades.
• Dissolution Advice: As an alcohol-soluble powder, it should be pre-dissolved in the alcohol or oil phase of the formulation.
• High Purity Benefits: The 95% purity grade is ideal for highly targeted serums and spot treatments.

6. Quality Assurance & Regulatory Confidence

We are committed to the highest standards of quality and regulatory compliance.

6.1 Certificate Section

Our quality and safety credentials include:

• COSMOS (Natural and Organic Cosmetic Standard)
• ISO 9001 Quality Management System
• ISO 22000 Food Safety Management System
• HALAL Certification
• IQNET (The International Certification Network)
• Technical Dossier (Certificate of Analysis – COA, Technical Data Sheet – TDS, Material Safety Data Sheet – MSDS)

7. Recommended Synergistic Combinations

• Licochalcone A + Ceramides: Combines anti-inflammatory repair with skin barrier restoration.
• Licochalcone A + Niacinamide: Synergistic in combating acne, redness, and inflammation.

8. Typical Applications & Success Stories

• Industry Validation: Used in high-end derma-cosmetic brands targeting sensitive, acne, and redness-prone skin.
• Product Categories: Anti-Aging Serums, Sensitive Skin Toners, Anti-Redness Creams, Post-Procedure Care.

9. Scientific Evidence & Literature Support

Based on internal lab summaries, our Licochalcone A provides powerful cellular protection:

9.1 Research Abstracts

• Anti-Aging and ROS Reduction: High ROS levels are a primary cause of cellular senescence. Compared to the control group, Licochalcone ALA at a concentration of 25 mol/L significantly reduced the ROS level in hADSCs (human adipose-derived stem cells) and suppressed telomere shortening (P < 0.05). This indicates its protective role against aging.

• Anti-Inflammatory Mechanism: LA reduces the release of pro-inflammatory factors, which helps prevent skin inflammation.
• Dual Action: LA demonstrates the function of inhibiting tyrosinase activity and exhibits a clear inhibitory effect on Staphylococcus aureus.

10. Stability and Safety Data Summary

• Safety: Derived from natural licorice, LA is generally well-tolerated and is used in sensitive skin products globally.
• Stability: All powder grades (20%, 70%, 95%) guarantee a 24-month shelf life when stored under recommended conditions.

11. Frequently Asked Questions (FAQ)

Q1: What is the recommended solvent for dissolving Licochalcone A 95%?

A: All grades of Licochalcone A are alcohol-soluble, making alcohol the primary recommended solvent for pre-dissolution.

Q2: Is Licochalcone A suitable for sensitive skin formulations?

A: Yes. Its primary function as an anti-inflammatory and soothing agent makes it highly suitable for sensitive, irritated, and redness-prone skin products.

Q3: How does Licochalcone A combat aging?

A: It works at the cellular level by reducing harmful ROS (free radicals) and suppressing the factors (P16ink4a) that drive cell senescence and telomere shortening.

Q4: Does Licochalcone A offer preservative benefits?

A: While its primary role is functional, it exhibits inhibitory effects against certain bacteria like Staphylococcus aureus, which contributes to overall formulation integrity.

Source the Advanced Natural Chalcone for Next-Generation Anti-Aging Formulas.

🔒 Get Your Technical Dossier: Access TDS, MSDS, COA and Safety Reports.

🔬 Apply for a Free Sample: Test the anti-inflammatory power of Licochalcone A today.

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