Gamma-Polyglutamic Acid is a natural, anionic biopolymer produced through the fermentation of Bacillus subtilis. It is celebrated as a super-humectant, capable of binding significantly more water than Hyaluronic Acid. Gamma-Polyglutamic Acid not only provides intensive, deep hydration but also uniquely enhances skin elasticity, inhibits the enzyme responsible for Hyaluronic Acid degradation, and improves the overall Skin Natural Moisturizing Factor (NMF) composition.
| INCI Name | Polyglutamic Acid |
|---|---|
| CAS No. | 25513-46-6 |
| Source | Biotechnological Fermentation |
| Appearance | White to off-white powder or viscous solution |
| Core Function | Super-Humectant, Elasticity Enhancement, HA Degradation Inhibition, NMF Boost, Barrier Support |
Are your premium hydrating serums losing their plumping effect hours after application due to endogenous enzymatic breakdown? For global procurement directors and senior cosmetic formulators, relying solely on traditional Hyaluronic Acid often results in short-lived surface moisture and tacky textures. The ultimate next-generation solution is Gamma-Polyglutamic Acid (γ-PGA). Engineered via advanced biological fermentation, this revolutionary polypeptide not only outperforms traditional humectants in sheer water retention but actively inhibits the enzymes that destroy the skin’s natural moisture matrix, delivering truly structural, anti-aging hydration.
In the competitive landscape of premium hydration, claims must be anchored in undeniable clinical science. We lead with verifiable laboratory data to guarantee the performance of your formulations:
5,000x Water-Binding Capacity: Its unique gamma-linkage molecular structure allows it to bind and hold up to 5,000 times its own weight in water, creating a powerful, sustained moisture reservoir within the skin.
24-Hour Superior Moisture Retention: Clinical comparative studies demonstrate that γ-PGA significantly outperforms Hyaluronic Acid at identical concentration levels in maintaining stratum corneum hydration over a full 24-hour period.
Direct Hyaluronidase Inhibition: In-vitro data confirms a significant reduction in the activity of Hyaluronidase—the enzyme responsible for breaking down the skin’s endogenous Hyaluronic Acid—actively preserving the skin’s natural youth and elasticity.
For Senior Formulators: Extreme Formula Compatibility
Achieve an elegant, non-tacky finish while maximizing hydration. Gamma-Polyglutamic Acid is highly water-soluble and exhibits excellent stability across a broad pH range of 4.0 to 7.0. Because it is an incredibly potent thickener, it allows you to achieve a luxurious serum viscosity at extremely low inclusion rates (0.05% – 0.2% for pure powder). Simply integrate it slowly into the aqueous phase with gentle stirring to prevent clumping. It serves as the ultimate highly compatible booster, working flawlessly alongside Niacinamide, Vitamin C derivatives, and your foundational humectant base.
For Brand Procurement: The Clean Beauty Top Choice
As a dedicated manufacturer of high-purity active ingredients, Shaanxi Huatai Bio-Fine Chemicals Co., Ltd. understands that your marketing narrative relies on the purity of your sources. Gamma-Polyglutamic Acid offers a compelling Clean Beauty story: a 100% natural, biotechnologically fermented active that provides intense moisture and barrier protection without synthetic film-formers. It allows your brand to claim next-generation, structural hydration and elevated elasticity, positioning your product in the highest tier of the cosmeceutical market.
| Parameter | Specification |
| Molecular Weight | Varies (Low to High Daltons, typically >100 kDa) |
| Purity | Standardized concentration in aqueous solution (e.g., 5% – 10%) |
| Recommended Dosage | 0.05% – 0.5% (as powder) or 1.0% – 5.0% (of a 5% solution) |
| Solubility | Highly Water Soluble |
| Stability Range | Excellent stability across pH 4.0 – 7.0 |
| Storage Conditions | Store in a cool, dark, and tightly sealed container. |
Accelerate your product development pipeline with these high-impact, synergistic combinations designed for premium dermatological applications:
The Deep-Hydrating Brightening Matrix: Combine Gamma-Polyglutamic Acid + Glabridin. Gamma-PGA locks in deep moisture and creates a breathable, protective surface film, optimizing the dermal environment and cellular hydration required for Glabridin to exert its powerful, targeted melanin-inhibiting properties.
The Ultimate Plumping & Firming Protocol: Pair Gamma-Polyglutamic Acid + Bakuchiol. The ultimate Clean Beauty anti-aging duo. Gamma-PGA protects endogenous hyaluronic acid and stimulates Natural Moisturizing Factors (NMF), while Bakuchiol gently accelerates collagen synthesis, resulting in rapidly visible wrinkle reduction without retinoid irritation.
The Multi-Layered Moisture Reservoir: Utilize Gamma-Polyglutamic Acid + Low-Molecular Hyaluronic Acid + Glycerin. Glycerin acts as the foundational moisture magnet, low-molecular HA plumps the cells, and the high-molecular γ-PGA locks the entire system down under a weightless, non-tacky film.
Our world-class manufacturing processes strictly adhere to the highest international quality and safety standards, ensuring your final products meet global compliance effortlessly. We proudly hold the following pure certifications:
ISO9001 Quality Management System
ISO22000 Food Safety Management System
COSMOS (Natural and Organic Cosmetic Standard)
HALAL Certification
IQNET (The International Certification Network)
Do not let outdated humectant technology and tacky textures hold your premium formulations back. Upgrade your active matrix with the industry standard for enzymatic protection and extreme water-binding capacity.
Ready to revolutionize your hydrating and anti-aging lines?
Empower your R&D and procurement teams today with uncompromising quality. Contact our B2B technical experts to access the complete Technical Dossier (TDS, MSDS, COA, and Clinical Efficacy Reports) and claim your high-purity, odorless free sample immediately! Ensure your next launch delivers the 24-hour structural hydration your consumers demand.
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