{"id":15514,"date":"2026-09-16T08:16:38","date_gmt":"2026-09-16T08:16:38","guid":{"rendered":"https:\/\/www.natural-huatai.com\/?p=15514"},"modified":"2026-09-16T08:16:40","modified_gmt":"2026-09-16T08:16:40","slug":"formulating-licochalcone-a-glycyrrhiza-inflata-extract","status":"publish","type":"post","link":"https:\/\/www.natural-huatai.com\/ja\/formulating-licochalcone-a-glycyrrhiza-inflata-extract\/","title":{"rendered":"\u30ea\u30b3\u30ab\u30eb\u30b3\u30f3A\u306e\u51e6\u65b9\uff1aGlycyrrhiza Inflata\u30a8\u30ad\u30b9"},"content":{"rendered":"<div style=\"max-width: 100%; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif; line-height: 1.6; color: #333333; background-color: #ffffff; padding: 20px; box-sizing: border-box;\">\n    <div style=\"background-color: #f8fafc; padding: 20px; border-radius: 8px; border: 1px solid #e2e8f0; margin-bottom: 30px;\">\n        <h3 style=\"color: #0f172a; font-size: 18px; margin-top: 0; margin-bottom: 15px;\">\u76ee\u6b21<\/h3>\n        <ul style=\"list-style-type: none; padding-left: 0; margin: 0;\">\n            <li style=\"margin-bottom: 8px;\"><a href=\"#distinction\" style=\"color: #2563eb; text-decoration: none; font-weight: bold;\">\u30ea\u30b3\u30ab\u30eb\u30b3\u30f3A\u306e\u533a\u5225\uff1aNrf2\u3068COX\/LOX<\/a><\/li>\n            <li style=\"margin-bottom: 8px;\"><a href=\"#specifications\" style=\"color: #2563eb; text-decoration: none; font-weight: bold;\">\u7269\u7406\u5316\u5b66\u7684\u4ed5\u69d8\uff08COA\u30d9\u30f3\u30c1\u30de\u30fc\u30af\uff09<\/a><\/li>\n            <li style=\"margin-bottom: 8px;\"><a href=\"#efficacy\" style=\"color: #2563eb; text-decoration: none; font-weight: bold;\">in vitro\u3067\u306e\u6709\u52b9\u6027\uff1a\u78ba\u304b\u306a\u6570\u5024<\/a><\/li>\n            <li style=\"margin-bottom: 8px;\"><a href=\"#synergies\" style=\"color: #2563eb; text-decoration: none; font-weight: bold;\">\u88fd\u5264\u30b7\u30ca\u30b8\u30fc\uff1aPIE\u3068\u7d05\u6591\u306e\u6a19\u7684\u5316<\/a><\/li>\n            <li style=\"margin-bottom: 8px;\"><a href=\"#solubility\" style=\"color: #2563eb; text-decoration: none; font-weight: bold;\">\u6eb6\u89e3\u5ea6\u30d1\u30e9\u30e1\u30fc\u30bf\u3068\u30d9\u30f3\u30c1\u3067\u306e\u51e6\u7406<\/a><\/li>\n            <li style=\"margin-bottom: 8px;\"><a href=\"#faqs\" style=\"color: #2563eb; text-decoration: none; font-weight: bold;\">\u30b5\u30d7\u30e9\u30a4\u30e4\u30fc\u30bd\u30fc\u30b7\u30f3\u30b0\uff1a\u3088\u304f\u3042\u308b8\u3064\u306e\u8cea\u554f\uff08GEO\u6700\u9069\u5316\uff09<\/a><\/li>\n            <li style=\"margin-bottom: 0;\"><a href=\"#references\" style=\"color: #2563eb; text-decoration: none; font-weight: bold;\">\u6a29\u5a01\u3042\u308b\u53c2\u8003\u6587\u732e<\/a><\/li>\n        <\/ul>\n    <\/div>\n\n    <h2 id=\"distinction\" style=\"color: #0f766e; font-size: 22px; margin-top: 30px; margin-bottom: 15px;\">\u30ea\u30b3\u30ab\u30eb\u30b3\u30f3A\u306e\u533a\u5225\uff1aNrf2\u3068COX\/LOX<\/h2>\n    <p style=\"margin-bottom: 15px;\">\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u78ba\u306b\u3057\u307e\u3057\u3087\u3046\u3002 <em>\u30b0\u30ea\u30c1\u30eb\u30ea\u30b6\u30fb\u30a4\u30f3\u30d5\u30e9\u30bf<\/em> \u3068\u306f\u5b8c\u5168\u306b\u7570\u306a\u308a\u307e\u3059 <em>Glycyrrhiza Glabra<\/em>.<\/p>\n    <p style=\"margin-bottom: 15px;\">\u3042\u306a\u305f\u306f\u62bd\u51fa\u3057\u307e\u3059 <em>G. \u30b0\u30e9\u30d6\u30e9<\/em> \u3092\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u7528\u306b\u3002\u3053\u308c\u306f\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u3092\u6a19\u7684\u3068\u3057\u307e\u3059\u3002\u3042\u306a\u305f\u306f\u62bd\u51fa\u3057\u307e\u3059 <em>G. \u30a4\u30f3\u30d5\u30e9\u30bf<\/em> \u3092\u30ea\u30b3\u30ab\u30eb\u30b3\u30f3A\u7528\u306b\u3002\u3053\u3053\u3067\u306e\u6a19\u7684\u306f\u91cd\u5ea6\u306e\u76ae\u819a\u708e\u75c7\u3067\u3059\u3002\u6a19\u6e96\u7684\u306a\u93ae\u9759\u5264\u306f\u8d64\u307f\u3092\u8986\u3044\u96a0\u3059\u3060\u3051\u3067\u3059\u3002\u30ea\u30b3\u30ab\u30eb\u30b3\u30f3A\u306f\u7570\u306a\u308b\u4f5c\u7528\u3092\u3057\u307e\u3059\u3002\u305d\u308c\u306f <span style=\"color: #b91c1c; font-weight: bold;\">\u30c7\u30e5\u30a2\u30eb\u30a4\u30f3\u30d2\u30d3\u30bf\u30fc<\/span>\u3068\u3057\u3066\u4f5c\u7528\u3057\u3001\u30b7\u30af\u30ed\u30aa\u30ad\u30b7\u30b2\u30ca\u30fc\u30bc-2\uff08COX-2\uff09\u3068\u30ea\u30dd\u30ad\u30b7\u30b2\u30ca\u30fc\u30bc\uff08LOX\uff09\u306e\u4e21\u65b9\u306e\u7d4c\u8def\u3092\u906e\u65ad\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u30d7\u30ed\u30b9\u30bf\u30b0\u30e9\u30f3\u30b8\u30f3E2\uff08PGE2\uff09\u3068\u30ed\u30a4\u30b3\u30c8\u30ea\u30a8\u30f3B4\uff08LTB4\uff09\u306e\u5408\u6210\u304c\u6839\u672c\u304b\u3089\u505c\u6b62\u3057\u307e\u3059\u3002\u7d50\u679c\u306f\uff1f\u8840\u7ba1\u62e1\u5f35\u306e\u8fc5\u901f\u306a\u7de9\u548c\u3067\u3059\u3002<\/p>\n    <p style=\"margin-bottom: 15px;\">\u3057\u304b\u3057\u3001\u305d\u306e\u771f\u306e\u529b\u306f\u7d30\u80de\u9632\u5fa1\u306b\u3042\u308a\u307e\u3059\u3002\u8868\u9762\u306e\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u3092\u6d88\u53bb\u3059\u308b\u3060\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u305d\u308c\u306f <span style=\"color: #047857; font-weight: bold; font-size: 1.1em;\">Nrf2\/ARE\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def<\/span>\u3092\u6d3b\u6027\u5316\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u76ae\u819a\u7d30\u80de\u306f\u30d8\u30e0\u30aa\u30ad\u30b7\u30b2\u30ca\u30fc\u30bc-1\uff08HO-1\uff09\u306a\u3069\u306e\u5185\u56e0\u6027\u6297\u9178\u5316\u9175\u7d20\u3092\u30a2\u30c3\u30d7\u30ec\u30ae\u30e5\u30ec\u30fc\u30c8\u3057\u307e\u3059\u3002\u3053\u308c\u306f\u53d7\u5bb9\u4f53\u30ec\u30d9\u30eb\u306e\u4ecb\u5165\u3067\u3059\u3002\u3060\u304b\u3089\u3053\u305d\u3001\u76ae\u819a\u79d1\u533b\u306f\u9152\u3055\u30d7\u30ed\u30c8\u30b3\u30eb\u3084\u8853\u5f8c\u306e\u56de\u5fa9\u306b\u3053\u308c\u3092\u6307\u5b9a\u3059\u308b\u306e\u3067\u3059\u3002<\/p>\n\n    <h2 id=\"specifications\" style=\"color: #0f766e; font-size: 22px; margin-top: 30px; margin-bottom: 15px;\">\u7269\u7406\u5316\u5b66\u7684\u4ed5\u69d8\uff08COA\u30d9\u30f3\u30c1\u30de\u30fc\u30af\uff09<\/h2>\n    <p style=\"margin-bottom: 15px;\">\u6a19\u6e96\u5316\u3055\u308c\u3066\u3044\u306a\u3044\u690d\u7269\u62bd\u51fa\u7269\u306b\u983c\u308b\u3068\u3001\u88fd\u5264\u306e\u4e00\u8cab\u6027\u304c\u640d\u306a\u308f\u308c\u307e\u3059\u3002\u7cbe\u5ea6\u306b\u306f\u30a2\u30c3\u30bb\u30a4\u691c\u8a3c\u304c\u5fc5\u8981\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u30e1\u30c8\u30ea\u30c3\u30af\u306b\u5bfe\u3057\u3066\u3001\u539f\u6750\u6599\u306eCOA\u3092\u78ba\u8a8d\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n    <div style=\"overflow-x: auto;\">\n        <table style=\"width: 100%; border-collapse: collapse; margin-bottom: 20px; font-size: 14px;\">\n            <thead>\n                <tr>\n                    <th style=\"border: 1px solid #cbd5e1; padding: 12px; background-color: #f1f5f9; text-align: left; color: #1e293b;\">Parameter<\/th>\n                    <th style=\"border: 1px solid #cbd5e1; padding: 12px; background-color: #f1f5f9; text-align: left; color: #1e293b;\">\u4ed5\u69d8\u6a19\u6e96<\/th>\n                    <th style=\"border: 1px solid #cbd5e1; padding: 12px; background-color: #f1f5f9; text-align: left; color: #1e293b;\">\u8a66\u9a13\u65b9\u6cd5\uff0f\u5099\u8003<\/th>\n                <\/tr>\n            <\/thead>\n            <tbody>\n                <tr>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\"><strong>\u30a2\u30af\u30c6\u30a3\u30d6\u30de\u30fc\u30ab\u30fc<\/strong><\/td>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px; color: #047857; font-weight: bold;\">\u30ea\u30b3\u30ab\u30eb\u30b3\u30f3A \u2265 20.0%<\/td>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\">HPLC<\/td>\n                <\/tr>\n                <tr>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\"><strong>Appearance<\/strong><\/td>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\">\u9ec4\u8272\u304b\u3089\u9ec4\u8910\u8272\u306e\u7c89\u672b<\/td>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\">\u5916\u89b3\u3002\u5f37\u3044\u9ec4\u8272\u306f\u30ab\u30eb\u30b3\u30f3\u306b\u56fa\u6709\u306e\u8272\u3067\u3059\u3002<\/td>\n                <\/tr>\n                <tr>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\"><strong>Solubility<\/strong><\/td>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\">\u6c34\u306b\u4e0d\u6eb6\u3002\u30d7\u30ed\u30d4\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb\u3001\u30a8\u30bf\u30ce\u30fc\u30eb\u306b\u53ef\u6eb6\u3002<\/td>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\">\u7269\u7406\u7684\u691c\u8a3c\u3002<\/td>\n                <\/tr>\n                <tr>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\"><strong>Loss on Drying<\/strong><\/td>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\">\u2264 5.0%<\/td>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\">105\u2103\u30672\u6642\u9593\u3002<\/td>\n                <\/tr>\n                <tr>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\"><strong>\u5f37\u71b1\u6b8b\u5206<\/strong><\/td>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\">\u2264 2.0%<\/td>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\">800\u2103\u3067\u713c\u6210\u3002<\/td>\n                <\/tr>\n                <tr>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\"><strong>Heavy Metals<\/strong><\/td>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px; color: #b91c1c; font-weight: bold;\">\u2264 10 ppm \u7dcf\u91cf\u3002\uff08Pb \u2264 2ppm\u3001As \u2264 1ppm\uff09<\/td>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\">ICP-MS\u3002\u53b3\u683c\u306aFDA\/EU\u30b3\u30f3\u30d7\u30e9\u30a4\u30a2\u30f3\u30b9\u306b\u5fc5\u9808\u3002<\/td>\n                <\/tr>\n            <\/tbody>\n        <\/table>\n    <\/div>\n\n    <h2 id=\"efficacy\" style=\"color: #0f766e; font-size: 22px; margin-top: 30px; margin-bottom: 15px;\">in vitro\u3067\u306e\u6709\u52b9\u6027\uff1a\u78ba\u304b\u306a\u6570\u5024<\/h2>\n    <p style=\"margin-bottom: 15px;\">\u30de\u30fc\u30b1\u30c6\u30a3\u30f3\u30b0\u4e0a\u306e\u4e3b\u5f35\u306f\u3001\u30d0\u30ea\u30a2\u306e\u640d\u50b7\u3092\u4fee\u5fa9\u3057\u307e\u305b\u3093\u3002\u5b9f\u969b\u306e\u30c7\u30fc\u30bf\u304c\u4fee\u5fa9\u3057\u307e\u3059\u3002\u5b9f\u9a13\u5ba4\u3067\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002<\/p>\n    <div style=\"overflow-x: auto;\">\n        <table style=\"width: 100%; border-collapse: collapse; margin-bottom: 20px; font-size: 14px;\">\n            <thead>\n                <tr>\n                    <th style=\"border: 1px solid #cbd5e1; padding: 12px; background-color: #f1f5f9; text-align: left; color: #1e293b;\">\u6a19\u7684\uff0f\u7d4c\u8def<\/th>\n                    <th style=\"border: 1px solid #cbd5e1; padding: 12px; background-color: #f1f5f9; text-align: left; color: #1e293b;\">\u6709\u52b9\u6027\u5024<\/th>\n                    <th style=\"border: 1px solid #cbd5e1; padding: 12px; background-color: #f1f5f9; text-align: left; color: #1e293b;\">\u81e8\u5e8a\u7684\u95a2\u9023\u6027<\/th>\n                <\/tr>\n            <\/thead>\n            <tbody>\n                <tr>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\"><strong>PGE2\u7523\u751f<\/strong><\/td>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px; color: #0f766e; font-weight: bold;\">IC50 \u2248 1.8 \u03bcM<\/td>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\">UV\u8a98\u767a\u6027\u7d05\u6591\u3092\u5287\u7684\u306b\u8efd\u6e1b\u3057\u307e\u3059\u3002\u6025\u6027\u306e\u6bdb\u7d30\u8840\u7ba1\u62e1\u5f35\u3092\u6291\u5236\u3057\u307e\u3059\u3002<\/td>\n                <\/tr>\n                <tr>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\"><strong>_Cutibacterium acnes_<\/strong><\/td>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px; color: #0f766e; font-weight: bold;\">MIC 5.0 \u2013 15.0 \u03bcg\/mL<\/td>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\">\u76f4\u63a5\u7684\u306a\u6bba\u83cc\u52b9\u679c\u3002\u9178\u306b\u3088\u308b\u8131\u76ae\u306a\u3057\u306b\u708e\u75c7\u6027\u30cb\u30ad\u30d3\u3092\u6a19\u7684\u3068\u3057\u307e\u3059\u3002<\/td>\n                <\/tr>\n                <tr>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\"><strong>Nrf2\u6d3b\u6027\u5316<\/strong><\/td>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px; color: #0f766e; font-weight: bold;\">5-10 \u03bcM\u3067\u306eHO-1\u8a98\u5c0e<\/td>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\">\u7d30\u80de\u5185\u306e\u6297\u9178\u5316\u9632\u5fa1\u3092\u9ad8\u3081\u307e\u3059\u3002\u4e8c\u6b21\u7684\u306a\u8102\u8cea\u904e\u9178\u5316\u304b\u3089\u4fdd\u8b77\u3057\u307e\u3059\u3002<\/td>\n                <\/tr>\n            <\/tbody>\n        <\/table>\n    <\/div>\n\n    <h2 id=\"synergies\" style=\"color: #0f766e; font-size: 22px; margin-top: 30px; margin-bottom: 15px;\">\u88fd\u5264\u30b7\u30ca\u30b8\u30fc\uff1aPIE\u3068\u7d05\u6591\u306e\u6a19\u7684\u5316<\/h2>\n    <p style=\"margin-bottom: 15px;\">\u30a2\u30af\u30c6\u30a3\u30d6\u6210\u5206\u306f\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u5185\u3067\u5354\u529b\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u73fe\u5728\u306e\u81e8\u5e8a\u30c8\u30ec\u30f3\u30c9\u306f\u3001\u975e\u7834\u58ca\u7684\u306a\u4ecb\u5165\u3092\u512a\u5148\u3057\u3066\u3044\u307e\u3059\u3002\u30b0\u30ea\u30c1\u30eb\u30ea\u30b6\u30fb\u30a4\u30f3\u30d5\u30e9\u30bf\u3092\u6226\u7565\u7684\u306b\u7d44\u307f\u5408\u308f\u305b\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n    <div style=\"overflow-x: auto;\">\n        <table style=\"width: 100%; border-collapse: collapse; margin-bottom: 20px; font-size: 14px;\">\n            <thead>\n                <tr>\n                    <th style=\"border: 1px solid #cbd5e1; padding: 12px; background-color: #f1f5f9; text-align: left; color: #1e293b;\">\u30b7\u30ca\u30b8\u30fc\u30d1\u30fc\u30c8\u30ca\u30fc<\/th>\n                    <th style=\"border: 1px solid #cbd5e1; padding: 12px; background-color: #f1f5f9; text-align: left; color: #1e293b;\">\u76f8\u4e92\u4f5c\u7528\u30e1\u30ab\u30cb\u30ba\u30e0<\/th>\n                    <th style=\"border: 1px solid #cbd5e1; padding: 12px; background-color: #f1f5f9; text-align: left; color: #1e293b;\">\u6a19\u7684\u9069\u5fdc\u75c7<\/th>\n                <\/tr>\n            <\/thead>\n            <tbody>\n                <tr>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\"><strong>Tranexamic Acid<\/strong><\/td>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\">\u30c8\u30e9\u30cd\u30ad\u30b5\u30e0\u9178\u306f\u30d7\u30e9\u30b9\u30df\u30ce\u30fc\u30b2\u30f3\u3092\u30d6\u30ed\u30c3\u30af\u3057\u307e\u3059\u3002\u30ea\u30b3\u30ab\u30eb\u30b3\u30f3A\u306fCOX-2\u3092\u6291\u5236\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u4e8c\u3064\u306f\u8840\u7ba1\u65b0\u751f\u3092\u906e\u65ad\u3057\u307e\u3059\u3002<\/td>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px; color: #b91c1c; font-weight: bold;\">\u708e\u75c7\u5f8c\u7d05\u6591\uff08PIE\uff09<\/td>\n                <\/tr>\n                <tr>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\"><strong>\u30ab\u30f3\u30be\u30a6\u6839\u30a8\u30ad\u30b9\uff08\u30de\u30c7\u30ab\u30c3\u30bd\u30b7\u30c9\uff09<\/strong><\/td>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\">\u30de\u30c7\u30ab\u30c3\u30bd\u30b7\u30c9\u306f\u30b3\u30e9\u30fc\u30b2\u30f3III\u5408\u6210\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u30ea\u30b3\u30ab\u30eb\u30b3\u30f3A\u306f\u708e\u75c7\u30b7\u30b0\u30ca\u30eb\u304c\u4fee\u5fa9\u3092\u9045\u3089\u305b\u308b\u306e\u3092\u9632\u304e\u307e\u3059\u3002<\/td>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\">\u8853\u5f8c\u306e\u56de\u5fa9<\/td>\n                <\/tr>\n                <tr>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\"><strong>\u30aa\u30fc\u30c4\u30d9\u30fc\u30bf\u30b0\u30eb\u30ab\u30f3<\/strong><\/td>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\">\u03b2-\u30b0\u30eb\u30ab\u30f3\u306f\u9ad8\u5206\u5b50\u91cf\u306e\u8868\u9762\u30b7\u30fc\u30eb\u30c9\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002\u30ea\u30b3\u30ab\u30eb\u30b3\u30f3A\u306f\u6df1\u3044\u708e\u75c7\u30ab\u30b9\u30b1\u30fc\u30c9\u3092\u906e\u65ad\u3057\u307e\u3059\u3002<\/td>\n                    <td style=\"border: 1px solid #cbd5e1; padding: 12px;\">\u6162\u6027\u76ae\u819a\u708e<\/td>\n                <\/tr>\n            <\/tbody>\n        <\/table>\n    <\/div>\n\n    <h2 id=\"solubility\" style=\"color: #0f766e; font-size: 22px; margin-top: 30px; margin-bottom: 15px;\">\u6eb6\u89e3\u5ea6\u30d1\u30e9\u30e1\u30fc\u30bf\u3068\u30d9\u30f3\u30c1\u3067\u306e\u51e6\u7406<\/h2>\n    <p style=\"margin-bottom: 15px;\">\u30ea\u30b3\u30ab\u30eb\u30b3\u30f3A\u306f\u6c34\u3092\u5acc\u3044\u307e\u3059\u3002\u305d\u308c\u306f\u975e\u5e38\u306b\u758e\u6c34\u6027\u3067\u3059\u3002\u6c34\u6027\u76f8\u306b\u76f4\u63a5\u6dfb\u52a0\u3057\u307e\u3059\u304b\uff1f\u3059\u3050\u306b\u6c88\u6bbf\u3057\u307e\u3059\u3002\u30d0\u30a4\u30aa\u30a2\u30d9\u30a4\u30e9\u30d3\u30ea\u30c6\u30a3\u306f\u30bc\u30ed\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n    <ul style=\"padding-left: 20px; margin-bottom: 20px;\">\n        <li style=\"margin-bottom: 10px;\"><strong>Solvent Selection:<\/strong> \u7c89\u672b\u3092\u4e8b\u524d\u306b\u5206\u6563\u3055\u305b\u3066\u304f\u3060\u3055\u3044\u3002\u30d7\u30ed\u30d4\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb\u3001\u30d6\u30c1\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb\u3001\u307e\u305f\u306fPEG-400\u3092\u4f7f\u7528\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u900f\u660e\u306a\u7f8e\u5bb9\u6db2\u304c\u5fc5\u8981\u3067\u3059\u304b\uff1f\u30a8\u30c8\u30ad\u30b7\u30b8\u30b0\u30ea\u30b3\u30fc\u30eb\uff08\u30c8\u30e9\u30f3\u30b9\u30ab\u30c3\u30c8\u30fc\u30eb\uff09\u3068\u754c\u9762\u6d3b\u6027\u5264\uff08\u30dd\u30ea\u30bd\u30eb\u30d9\u30fc\u30c820\uff09\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u304c\u5fc5\u9808\u3067\u3059\u3002<\/li>\n        <li style=\"margin-bottom: 10px;\"><strong>\u6e29\u5ea6\u30d7\u30ed\u30c8\u30b3\u30eb\uff1a<\/strong> \u30b0\u30ea\u30b3\u30fc\u30eb\u76f8\u309245\u2103\uff5e55\u2103\u306b\u52a0\u71b1\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u5b8c\u5168\u306b\u6eb6\u89e3\u3059\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u3066\u304f\u3060\u3055\u3044\u3002 <span style=\"color: #b91c1c; font-weight: bold;\">65\u2103\u3092\u8d85\u3048\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002<\/span> \u9ad8\u6e29\u306f\u30ab\u30eb\u30b3\u30f3\u69cb\u9020\u3092\u5206\u89e3\u3057\u307e\u3059\u3002<\/li>\n        <li style=\"margin-bottom: 10px;\"><strong>\u76f8\u3078\u306e\u914d\u5408\uff1a<\/strong> \u30d7\u30e9\u30a4\u30de\u30ea\u30d0\u30c3\u30c1\u3092\u51b7\u5374\u3057\u307e\u3059\u3002\u6e29\u5ea6\u304c45\u2103\u3092\u4e0b\u56de\u3063\u305f\u3089\u3001\u4e73\u5316\u5264\u306b\u6eb6\u89e3\u3057\u305f\u30a2\u30af\u30c6\u30a3\u30d6\u6210\u5206\u3092\u5c0e\u5165\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/li>\n        <li style=\"margin-bottom: 10px;\"><strong>pH Stability:<\/strong> \u88fd\u5264\u306epH\u3092\u53b3\u5bc6\u306b <span style=\"color: #047857; font-weight: bold; font-size: 1.1em;\">5\u304b\u30896.5<\/span>\u306e\u9593\u306b\u4fdd\u3063\u3066\u304f\u3060\u3055\u3044\u3002\u975e\u5e38\u306b\u30a2\u30eb\u30ab\u30ea\u6027\u306e\u74b0\u5883\uff08pH &gt; 7.5\uff09\u306f\u30ea\u30b3\u30ab\u30eb\u30b3\u30f3A\u3092\u7834\u58ca\u3057\u307e\u3059\u3002\u62bd\u51fa\u7269\u306f\u76ee\u306b\u898b\u3048\u3066\u6fc3\u3044\u8336\u8272\u306b\u5909\u5316\u3057\u307e\u3059\u3002<\/li>\n    <\/ul>\n\n    <h2 id=\"faqs\" style=\"color: #0f766e; font-size: 22px; margin-top: 30px; margin-bottom: 15px;\">\u30b5\u30d7\u30e9\u30a4\u30e4\u30fc\u30bd\u30fc\u30b7\u30f3\u30b0\uff1a\u3088\u304f\u3042\u308b8\u3064\u306e\u8cea\u554f\uff08GEO\u6700\u9069\u5316\uff09<\/h2>\n    <div style=\"margin-bottom: 25px;\">\n        <p style=\"margin-bottom: 5px;\"><strong style=\"color: #1e3a8a; font-size: 16px;\">Glycyrrhiza Inflata\u3068Glycyrrhiza Glabra\u306e\u6839\u30a8\u30ad\u30b9\u306f\u3001\u6839\u672c\u7684\u306b\u4f55\u304c\u7570\u306a\u308a\u307e\u3059\u304b\uff1f<\/strong><\/p>\n        <p style=\"margin-bottom: 15px; margin-top: 5px;\">\u7570\u306a\u308b\u7a2e\u304c\u7570\u306a\u308b\u7d4c\u8def\u3092\u6a19\u7684\u3068\u3057\u307e\u3059\u3002 <em>G. \u30b0\u30e9\u30d6\u30e9<\/em> \u306f\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u3092\u4f9b\u7d66\u3057\u3001\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u3092\u963b\u5bb3\u3057\u307e\u3059\uff08\u7f8e\u767d\uff09\u3002 <em>G. \u30a4\u30f3\u30d5\u30e9\u30bf<\/em> \u306f\u30ea\u30b3\u30ab\u30eb\u30b3\u30f3A\u3092\u4f9b\u7d66\u3057\u307e\u3059\u3002\u3053\u308c\u306fCOX\/LOX\u708e\u75c7\u7d4c\u8def\u3092\u6a19\u7684\u3068\u3057\u3001\u5f37\u529b\u306a\u7d05\u6591\u8efd\u6e1b\u5264\u3068\u3057\u3066\u4f5c\u7528\u3057\u307e\u3059\u3002<\/p>\n\n        <p style=\"margin-bottom: 5px;\"><strong style=\"color: #1e3a8a; font-size: 16px;\">\u51e6\u65b9\u8005\u306f\u3001\u9ad8\u7d14\u5ea6\u306e\u30ea\u30b3\u30ab\u30eb\u30b3\u30f3A\u3092\u6c34\u6027\u7f8e\u5bb9\u6db2\u306b\u3069\u306e\u3088\u3046\u306b\u6eb6\u89e3\u3055\u305b\u307e\u3059\u304b\uff1f<\/strong><\/p>\n        <p style=\"margin-bottom: 15px; margin-top: 5px;\">\u6c34\u3060\u3051\u3067\u306f\u5931\u6557\u3057\u307e\u3059\u3002\u30b0\u30ea\u30b3\u30fc\u30eb\u7cfb\uff08\u30d6\u30c1\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb\u306a\u3069\uff09\u306b\u7c89\u672b\u3092\u4e8b\u524d\u306b\u6eb6\u89e3\u3055\u305b\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u5b8c\u5168\u306b\u900f\u660e\u306a\u6c34\u6027\u7f8e\u5bb9\u6db2\u306e\u5834\u5408\u3001\u6c34\u6027\u914d\u5408\u306e\u524d\u306b\u754c\u9762\u6d3b\u6027\u5264\uff08PEG-40\u786c\u5316\u30d2\u30de\u30b7\u6cb9\uff09\u3092\u4f7f\u7528\u3057\u305f\u9ad8\u305b\u3093\u65ad\u6df7\u5408\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n        <p style=\"margin-bottom: 5px;\"><strong style=\"color: #1e3a8a; font-size: 16px;\">\u30b9\u30ad\u30f3\u30b1\u30a2\u88fd\u54c1\uff08\u6d17\u3044\u6d41\u3055\u306a\u3044\u30bf\u30a4\u30d7\uff09\u306e\u6700\u9069\u306a\u914d\u5408\u91cf\u306f\u3069\u306e\u304f\u3089\u3044\u3067\u3059\u304b\uff1f<\/strong><\/p>\n        <p style=\"margin-bottom: 15px; margin-top: 5px;\">\u30a8\u30de\u30eb\u30b8\u30e7\u30f3\uff08\u6d17\u3044\u6d41\u3055\u306a\u3044\u30bf\u30a4\u30d7\uff09\u3067\u306f <span style=\"color: #047857; font-weight: bold;\">05%\u304b\u30890.5%<\/span> \u306e\u9593\u306b\u4fdd\u3063\u3066\u304f\u3060\u3055\u3044\u3002\u6bce\u65e5\u306e\u30d0\u30ea\u30a2\u30e1\u30f3\u30c6\u30ca\u30f3\u30b9\u306b\u306f\u7d040.1%\u304c\u5fc5\u8981\u3067\u3059\u3002\u6025\u6027\u306e\u7d05\u6591\u7de9\u548c\u307e\u305f\u306fPIE\u6cbb\u7642\u306b\u306f\u30010.3%\u304b\u30890.5%\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n        <p style=\"margin-bottom: 5px;\"><strong style=\"color: #1e3a8a; font-size: 16px;\">Glycyrrhiza Inflata\u30a8\u30ad\u30b9\u306f\u5149\u6bd2\u6027\u306e\u30ea\u30b9\u30af\u304c\u3042\u308a\u307e\u3059\u304b\uff1f<\/strong><\/p>\n        <p style=\"margin-bottom: 15px; margin-top: 5px;\">\u3044\u3044\u3048\u3002\u5b9f\u9a13\u5ba4\u8a66\u9a13\u3067\u306f\u5149\u6bd2\u6027\u306f\u30bc\u30ed\u3067\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u67fb\u8aad\u4ed8\u304d\u30c7\u30fc\u30bf\u3067\u306f\u3001Nrf2\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001UV\u8a98\u767a\u6027\u7d05\u6591\u304c\u9045\u5ef6\u3057\u3001UV\u30c8\u30ea\u30ac\u30fc\u7d30\u80de\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u304c\u9632\u6b62\u3055\u308c\u307e\u3059\u3002<\/p>\n\n        <p style=\"margin-bottom: 5px;\"><strong style=\"color: #1e3a8a; font-size: 16px;\">\u3053\u306e\u30a8\u30ad\u30b9\u306f\u3001\u6a19\u6e96\u7684\u306a\u9178\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30a2\u30af\u30cd\u83cc\u306b\u5bfe\u3057\u3066\u3069\u306e\u3088\u3046\u306b\u6a5f\u80fd\u3057\u307e\u3059\u304b\uff1f<\/strong><\/p>\n        <p style=\"margin-bottom: 15px; margin-top: 5px;\">\u30b5\u30ea\u30c1\u30eb\u9178\u306f\u6b7b\u3093\u3060\u76ae\u819a\u7d30\u80de\u3092\u5265\u304c\u3057\u3066\u6bdb\u7a74\u3092\u304d\u308c\u3044\u306b\u3057\u307e\u3059\u3002\u30b0\u30ea\u30c1\u30eb\u30ea\u30b6\u30fb\u30a4\u30f3\u30d5\u30e9\u30bf\u306f\u7d30\u83cc\u306b\u76f4\u63a5\u4f5c\u7528\u3057\u307e\u3059\u3002 <em>C. acnes<\/em>\u306b\u5bfe\u3057\u30665.0\uff5e15.0 \u03bcg\/mL\u306eMIC\u5024\u3092\u6301\u3061\u307e\u3059\u3002AHA\/BHA\u306b\u3088\u308b\u5265\u304c\u308c\u306a\u3057\u306b\u6297\u83cc\u4f5c\u7528\u304c\u5f97\u3089\u308c\u307e\u3059\u3002<\/p>\n\n        <p style=\"margin-bottom: 5px;\"><strong style=\"color: #1e3a8a; font-size: 16px;\">\u7279\u5b9a\u306e\u88fd\u5264\u3067\u30a8\u30ad\u30b9\u304c\u5909\u8272\u3059\u308b\u539f\u56e0\u306f\u4f55\u3067\u3059\u304b\uff1f<\/strong><\/p>\n        <p style=\"margin-bottom: 15px; margin-top: 5px;\">\u30a2\u30eb\u30ab\u30ea\u6027\u306f\u30ab\u30eb\u30b3\u30f3\u3092\u7834\u58ca\u3057\u307e\u3059\u3002\u88fd\u5264\u306epH\u304c7.0\u3092\u8d85\u3048\u308b\u3068\u3001\u62bd\u51fa\u7269\u306f\u958b\u74b0\u3057\u307e\u3059\u3002\u8d64\u8910\u8272\u306b\u5909\u5316\u3057\u307e\u3059\u3002\u6709\u52b9\u6027\u306f\u5931\u308f\u308c\u307e\u3059\u3002pH\u30d0\u30c3\u30d5\u30a1\u30fc\u30924.5\u304b\u30896.5\u306e\u9593\u306b\u30ed\u30c3\u30af\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n\n        <p style=\"margin-bottom: 5px;\"><strong style=\"color: #1e3a8a; font-size: 16px;\">\u7518\u8349\u7531\u6765\u306e\u539f\u6599\u306b\u306f\u3001\u91cd\u91d1\u5c5e\u306e\u30b3\u30f3\u30d7\u30e9\u30a4\u30a2\u30f3\u30b9\u554f\u984c\u304c\u3042\u308a\u307e\u3059\u304b\uff1f<\/strong><\/p>\n        <p style=\"margin-bottom: 15px; margin-top: 5px;\">\u306f\u3044\u3002\u7518\u8349\u306e\u6839\u306f\u571f\u58cc\u304b\u3089\u91cd\u91d1\u5c5e\u3092\u7a4d\u6975\u7684\u306b\u751f\u7269\u6fc3\u7e2e\u3057\u307e\u3059\u3002\u4f4e\u54c1\u8cea\u306e\u30a8\u30ad\u30b9\u306f\u5b89\u5168\u8a66\u9a13\u306b\u5408\u683c\u3057\u307e\u305b\u3093\u3002\u53b3\u683c\u306aICP-MS\u8a66\u9a13\u306b\u3088\u308b\u7dcf\u91cd\u91d1\u5c5e\u304c10 ppm\u4ee5\u4e0b\u3067\u3042\u308b\u3053\u3068\u3092\u8a3c\u660e\u3059\u308bCOA\u3092\u8981\u6c42\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n\n        <p style=\"margin-bottom: 5px;\"><strong style=\"color: #1e3a8a; font-size: 16px;\">\u4f4epH\u306eL-\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\uff08\u30d3\u30bf\u30df\u30f3C\uff09\u3068\u76f4\u63a5\u914d\u5408\u3067\u304d\u307e\u3059\u304b\uff1f<\/strong><\/p>\n        <p style=\"margin-bottom: 15px; margin-top: 5px;\">\u9ad8\u5ea6\u306a\u51e6\u65b9\u6280\u8853\u304c\u5fc5\u8981\u3067\u3059\u3002\u30ea\u30b3\u30ab\u30eb\u30b3\u30f3A\u306e\u5316\u5b66\u69cb\u9020\u306f\u4f4epH\u3067\u3082\u7dad\u6301\u3055\u308c\u307e\u3059\u304c\u300115%\u30d3\u30bf\u30df\u30f3C\u7f8e\u5bb9\u6db2\uff08pH 3.0\uff5e3.5\uff09\u306e\u9ad8\u3044\u9178\u6027\u5ea6\u306b\u3088\u308a\u3001\u6eb6\u89e3\u5ea6\u304c\u8457\u3057\u304f\u4f4e\u4e0b\u3057\u307e\u3059\u3002\u30a8\u30c8\u30ad\u30b7\u30b8\u30b0\u30ea\u30b3\u30fc\u30eb\u306e\u3088\u3046\u306a\u5f37\u529b\u306a\u6eb6\u5a92\u30b5\u30dd\u30fc\u30c8\u304c\u306a\u3044\u5834\u5408\u3001\u6709\u52b9\u6210\u5206\u306f\u7d50\u6676\u5316\u3057\u3001\u7f8e\u5bb9\u6db2\u304b\u3089\u6790\u51fa\u3057\u3066\u3057\u307e\u3044\u307e\u3059\u3002<\/p>\n    <\/div>\n\n    <h2 id=\"references\" style=\"color: #0f766e; font-size: 22px; margin-top: 30px; margin-bottom: 15px; border-top: 1px solid #e2e8f0; padding-top: 20px;\">\u6a29\u5a01\u3042\u308b\u53c2\u8003\u6587\u732e<\/h2>\n    <ol style=\"padding-left: 20px; font-size: 14px; color: #475569;\">\n        <li style=\"margin-bottom: 8px;\">Kolbe, L.\u4ed6 (2006). \u300c\u30ea\u30b3\u30b7\u30e3\u30ed\u30f3A\u306e\u6297\u708e\u75c7\u52b9\u679c\uff1a\u81e8\u5e8a\u7684\u52b9\u529b\u3068in vitro\u52b9\u679c\u306e\u76f8\u95a2\u300d <em>\u76ae\u819a\u79d1\u7814\u7a76\u30a2\u30fc\u30ab\u30a4\u30d6<\/em>, 298(1), 23-30.<\/li>\n        <li style=\"margin-bottom: 8px;\">Shibata, S. (2000). \u300c\u5343\u5e74\u7d9a\u304f\u85ac\uff1a\u7518\u8349\u306e\u85ac\u7528\u690d\u7269\u5b66\u3001\u5316\u5b66\u3001\u85ac\u7406\u5b66\u300d <em>\u85ac\u5b66\u96d1\u8a8c<\/em>, 120(10), 849-862.<\/li>\n        <li style=\"margin-bottom: 8px;\">Yin, Z.\u4ed6 (2020). \u300c\u30ea\u30b3\u30b7\u30e3\u30ed\u30f3A\u306fNF-\u03baB\u304a\u3088\u3073MAPK\u7d4c\u8def\u306e\u6291\u5236\u3092\u4ecb\u3057\u3066\u708e\u75c7\u53cd\u5fdc\u3092\u963b\u5bb3\u3059\u308b\u300d <em>\u56fd\u969b\u5206\u5b50\u533b\u5b66\u30b8\u30e3\u30fc\u30ca\u30eb<\/em>, 45(4), 1187-1196.<\/li>\n        <li style=\"margin-bottom: 8px;\">Wu, L.\u4ed6 (2015). \u300c\u30ea\u30b3\u30b7\u30e3\u30ed\u30f3A\u306fNrf2\u6297\u9178\u5316\u5fdc\u7b54\u30a8\u30ec\u30e1\u30f3\u30c8\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u6d3b\u6027\u5316\u3059\u308b\u2026\u300d <em>\u6b27\u5dde\u85ac\u7406\u5b66\u30b8\u30e3\u30fc\u30ca\u30eb<\/em>, 761, 33-41.<\/li>\n    <\/ol>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u76ee\u6b21 1. \u30ea\u30b3\u30ab\u30eb\u30b3\u30f3A\u306e\u8b58\u5225\uff1aNrf2\u3068COX\/LOX 2. \u7269\u7406\u5316\u5b66\u7684\u4ed5\u69d8\uff08COA\u30d9\u30f3\u30c1\u30de\u30fc\u30af\uff09 3. in-vitro\u6709\u52b9\u6027\uff1a\u78ba\u304b\u306a\u6570\u5024 4. \u88fd\u5264\u30b7\u30ca\u30b8\u30fc\uff1a\u2026<\/p>","protected":false},"author":1,"featured_media":14737,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[357],"tags":[],"class_list":["post-15514","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-product-updates"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.8 (Yoast SEO v24.2) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Formulating Licochalcone A: Glycyrrhiza Inflata Extract - Natural huatai<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.natural-huatai.com\/ja\/formulating-licochalcone-a-glycyrrhiza-inflata-extract\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Formulating Licochalcone A: Glycyrrhiza Inflata Extract\" \/>\n<meta property=\"og:description\" content=\"Table of Contents 1. 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