{"id":15482,"date":"2026-09-10T09:28:28","date_gmt":"2026-09-10T09:28:28","guid":{"rendered":"https:\/\/www.natural-huatai.com\/?p=15482"},"modified":"2026-09-10T09:28:29","modified_gmt":"2026-09-10T09:28:29","slug":"glabridin-and-melanogenesis-understanding-its-role-in-pigment-biology","status":"publish","type":"post","link":"https:\/\/www.natural-huatai.com\/ja\/glabridin-and-melanogenesis-understanding-its-role-in-pigment-biology\/","title":{"rendered":"\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u3068\u30e1\u30e9\u30cb\u30f3\u751f\u6210\uff1a\u8272\u7d20\u751f\u7269\u5b66\u306b\u304a\u3051\u308b\u305d\u306e\u5f79\u5272\u306e\u7406\u89e3"},"content":{"rendered":"
\n

\n \u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u306f\u3001\u5b9f\u9a13\u5ba4\u3067\u306e\u30c7\u30fc\u30bf\u304c\u305d\u306e\u5f8c\u306e\u958b\u767a\u4f5c\u696d\u3088\u308a\u3082\u5358\u7d14\u306b\u898b\u3048\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u5316\u7ca7\u54c1\u6709\u52b9\u6210\u5206\u306e\u4e00\u3064\u3067\u3059\u3002\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u963b\u5bb3\u306f\u3001\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u304c\u30e1\u30e9\u30cb\u30f3\u5408\u6210\u306b\u76f4\u63a5\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u9175\u7d20\u30a2\u30c3\u30bb\u30a4\u306f\u6bd4\u8f03\u7684\u7c21\u5358\u306b\u5b9f\u65bd\u30fb\u6bd4\u8f03\u3067\u304d\u308b\u305f\u3081\u3001\u901a\u5e38\u3001\u6700\u521d\u306b\u30ec\u30d3\u30e5\u30fc\u3055\u308c\u308b\u7d50\u679c\u306e\u4e00\u3064\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u51e6\u65b9\u30c1\u30fc\u30e0\u306f\u6700\u7d42\u7684\u306b\u7570\u306a\u308b\u7591\u554f\u3092\u6295\u3052\u304b\u3051\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002 \u30a2\u30c3\u30bb\u30a4\u306f\u5b9f\u969b\u306b\u4f55\u3092\u6559\u3048\u3066\u304f\u308c\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u89b3\u5bdf\u3055\u308c\u305f\u6d3b\u6027\u306f\u518d\u73fe\u53ef\u80fd\u3067\u3057\u3087\u3046\u304b\uff1f\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u3092\u8d85\u3048\u3066\u5e83\u304c\u3063\u3066\u3044\u307e\u3059\u304b\uff1f\u305d\u3057\u3066\u3001\u305d\u306e\u6210\u5206\u306f\u5b9f\u7528\u7684\u306a\u4fa1\u5024\u3092\u5931\u3046\u3053\u3068\u306a\u304f\u3001\u610f\u56f3\u3057\u305f\u51e6\u65b9\u306b\u7d44\u307f\u8fbc\u3080\u3053\u3068\u304c\u3067\u304d\u308b\u3067\u3057\u3087\u3046\u304b\uff1f<\/strong>\n <\/p>\n\n

\n \u30b0\u30e9\u30d6\u30ea\u30b8\u30f3 vs. \u7518\u8349\u30a8\u30ad\u30b9\n <\/h2>\n

\n \u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u306f\u3001\u301c\u306e\u6839\u306b\u542b\u307e\u308c\u308b\u30d7\u30ec\u30cb\u30eb\u5316\u3055\u308c\u305f\u30a4\u30bd\u30d5\u30e9\u30d0\u30f3\u3067\u3059\u3002 \u30ab\u30f3\u30be\u30a6<\/em> \uff08\u7518\u8349\uff09\u3002\u8a55\u4fa1\u4e2d\u306b\u7cbe\u88fd\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u3068\u4e00\u822c\u7684\u306a\u7518\u8349\u30a8\u30ad\u30b9\u3092\u533a\u5225\u3059\u308b\u3053\u3068\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002\n <\/p>\n \n

\n
    \n
  • \u7518\u8349\u30a8\u30ad\u30b9\uff1a<\/strong> \u8907\u6570\u306e\u6210\u5206\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u7d44\u6210\u306f\u3001\u690d\u7269\u6750\u6599\u3001\u62bd\u51fa\u30d7\u30ed\u30bb\u30b9\u3001\u6eb6\u5a92\u30b7\u30b9\u30c6\u30e0\u3001\u6a19\u6e96\u5316\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u3002<\/li>\n
  • \u7cbe\u88fd\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\uff1a<\/strong> \u660e\u78ba\u306a\u5316\u5b66\u7684\u540c\u4e00\u6027\u3001\u53b3\u683c\u306a\u30a2\u30c3\u30bb\u30a4\u8981\u4ef6\u3001\u304a\u3088\u3073\u4e00\u8cab\u3057\u305f\u30d0\u30c3\u30c1\u4ed5\u69d8\u3092\u6301\u3064\u3001\u660e\u78ba\u306a\u6210\u5206\u3067\u3059\u3002<\/li>\n <\/ul>\n <\/div>\n\n

    \n \u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u30c7\u30fc\u30bf\u306e\u89e3\u8aad\n <\/h2>\n

    \n \u6a2a\u7530\u3089\u306b\u3088\u308b\u521d\u671f\u306e\u7814\u7a76\u3067\u306f\u3001\u301c\u3067\u306e\u7d30\u80de\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u963b\u5bb3\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u304c\u3001 1\u20131.0 \u03bcg\/mL<\/span>\u3001\u305d\u306e\u5f8c\u306e\u7814\u7a76\u3067\u8907\u96d1\u306a\u76f8\u4e92\u4f5c\u7528\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u30022016\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u301c\u3067\u53ef\u9006\u7684\u304b\u3064\u975e\u7af6\u5408\u7684\u306a\u963b\u5bb3\u304c\u6307\u6458\u3055\u308c\u307e\u3057\u305f\u3002 IC50\u304c0.43 \u03bcmol\/L<\/span>\u3001\u5206\u5b50\u30c9\u30c3\u30ad\u30f3\u30b0\u3067\u306f\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u6d3b\u6027\u90e8\u4f4d\u3078\u306e\u76f4\u63a5\u7684\u306a\u7d50\u5408\u306f\u793a\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002 \n <\/p>\n

    \n \u516c\u958b\u3055\u308c\u3066\u3044\u308bIC50\u5024\u306f\u3001\u9175\u7d20\u6e90\u3001\u57fa\u8cea\u6fc3\u5ea6\u3001pH\u3001\u304a\u3088\u3073\u5b9f\u9a13\u8a2d\u8a08\u306b\u5927\u304d\u304f\u4f9d\u5b58\u3057\u307e\u3059\u3002R&D\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u6570\u5024\u306f\u6709\u7528\u306a\u6307\u6a19\u3067\u3059\u304c\u3001\u6700\u7d42\u7684\u306a\u51e6\u65b9\u958b\u767a\u306b\u304a\u3044\u3066\u306f\u3001\u5fc5\u8981\u306a\u8a3c\u62e0\u306e\u3054\u304f\u4e00\u90e8\u3092\u8868\u3059\u306b\u3059\u304e\u307e\u305b\u3093\u3002\n <\/p>\n\n

    \n \u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u3092\u8d85\u3048\u3066\uff1a\u898f\u5236\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\n <\/h2>\n

    \n \u30e1\u30e9\u30ce\u30b8\u30a7\u30cd\u30b7\u30b9\u306f\u3001\u301c\u304c\u4e3b\u8981\u306a\u8ee2\u5199\u56e0\u5b50\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u5e83\u7bc4\u306a\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u3066\u3044\u307e\u3059\u3002 MITF<\/strong> \u301c\u3092\u8abf\u7bc0\u3057\u307e\u3059\u3002 TYR<\/span>, TRP-1<\/span>, and TRP-2<\/span>\u3002\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001\u3088\u308a\u5e83\u7bc4\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u7d4c\u8def\u304c\u5f37\u8abf\u3055\u308c\u3066\u3044\u307e\u3059\u3002\n <\/p>\n \n \n \n \n \n \n \n
    \u7814\u7a76\u306e\u7126\u70b9<\/th>\n \u4e3b\u306a\u767a\u898b\u3068\u7d4c\u8def<\/th>\n <\/tr>\n <\/thead>\n
    \u4e0a\u6d41\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054<\/td>\n PKA\/MITF\u3001MAPK\/MITF\u3001\u304a\u3088\u3073CREB\u30ea\u30f3\u9178\u5316\u7d4c\u8def\u3078\u306e\u95a2\u4e0e\u3002<\/td>\n <\/tr>\n
    \u6700\u8fd1\u306e\u767a\u898b\uff082025\u301c2026\u5e74\uff09<\/td>\n \u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u3068SOX10\u3001CRTC1\u95a2\u9023\u8abf\u7bc0\u3001Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3001\u304a\u3088\u3073\u30e1\u30e9\u30cb\u30f3\u8ee2\u9001\u306e\u6291\u5236\u3068\u306e\u95a2\u9023\u3092\u793a\u3059\u8a3c\u62e0\u3002<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n\n

    \n \u30b3\u30a2\u51e6\u65b9\u306e\u8ab2\u984c\n <\/h2>\n

    \n \u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u306f \u89aa\u6cb9\u6027\u3067\u6c34\u6eb6\u6027\u304c\u4f4e\u3044<\/span>\u3001\u6c34\u6027\u7f8e\u5bb9\u6db2\u3084\u4f4e\u6cb9\u6027\u30c7\u30ea\u30d0\u30ea\u30fc\u30b7\u30b9\u30c6\u30e0\u306b\u3068\u3063\u3066\u7279\u6709\u306e\u8ab2\u984c\u3068\u306a\u308a\u307e\u3059\u3002\u51e6\u65b9\u8005\u306f\u3001\u8907\u6570\u306e\u6280\u8853\u7684\u306a\u30cf\u30fc\u30c9\u30eb\u3092\u614e\u91cd\u306b\u4e57\u308a\u8d8a\u3048\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\n <\/p>\n

      \n
    • \u9078\u629e\u3055\u308c\u305f\u6cb9\u307e\u305f\u306f\u6eb6\u5a92\u30b7\u30b9\u30c6\u30e0\u3068\u306e\u9069\u5408\u6027<\/li>\n
    • \u4fdd\u7ba1\u4e2d\u306e\u6c88\u6bbf\u307e\u305f\u306f\u7d50\u6676\u5316\u306e\u30ea\u30b9\u30af<\/li>\n
    • \u52a0\u5de5\u6e29\u5ea6\u306e\u5236\u9650<\/li>\n
    • \u5149\u3001\u9178\u7d20\u3001\u304a\u3088\u3073\u5171\u6210\u5206\u306b\u5bfe\u3059\u308b\u611f\u5ea6<\/li>\n <\/ul>\n\n

      \n \u3088\u304f\u3042\u308b\u8cea\u554f\n <\/h2>\n \n
      \n

      \u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u306eIC50\u5024\u306f\u3001\u6700\u7d42\u88fd\u54c1\u306e\u6027\u80fd\u3092\u4e88\u6e2c\u3067\u304d\u307e\u3059\u304b\uff1f<\/p>\n

      \u3044\u3044\u3048\u3002IC50\u306f\u7279\u5b9a\u306e\u5b9f\u9a13\u30b7\u30b9\u30c6\u30e0\u3092\u53cd\u6620\u3057\u3066\u304a\u308a\u3001\u51e6\u65b9\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u3001\u76ae\u819a\u3078\u306e\u30c7\u30ea\u30d0\u30ea\u30fc\u3001\u5b89\u5b9a\u6027\u3001\u307e\u305f\u306f\u81e8\u5e8a\u6027\u80fd\u3092\u8003\u616e\u3057\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n <\/div>\n \n

      \n

      \u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u306f\u7518\u8349\u30a8\u30ad\u30b9\u3068\u540c\u7b49\u3067\u3059\u304b\uff1f<\/p>\n

      \u3044\u3044\u3048\u3002\u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u306f\u5316\u5b66\u7684\u306b\u5b9a\u7fa9\u3055\u308c\u305f\u7d14\u7c8b\u306a\u5316\u5408\u7269\u3067\u3059\u304c\u3001\u7518\u8349\u30a8\u30ad\u30b9\u306f\u8907\u6570\u306e\u6210\u5206\u306e\u5909\u52d5\u3059\u308b\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u542b\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n <\/div>\n\n

      \n

      \u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u3092\u8abf\u9054\u3059\u308b\u969b\u306b\u3001\u30d0\u30a4\u30e4\u30fc\u306f\u4f55\u3092\u512a\u5148\u3059\u3079\u304d\u3067\u3059\u304b\uff1f<\/p>\n

      \u57fa\u672c\u7684\u306a\u30a2\u30c3\u30bb\u30a4\u30b7\u30fc\u30c8\u306b\u52a0\u3048\u3066\u3001\u5b89\u5b9a\u6027\u30c7\u30fc\u30bf\u3001\u7269\u7406\u7684\u5f62\u614b\u306e\u4ed5\u69d8\u3001\u63a8\u5968\u3055\u308c\u308b\u53d6\u308a\u6271\u3044\u6761\u4ef6\u3001\u304a\u3088\u3073\u5805\u7262\u306a\u51e6\u65b9\u30b5\u30dd\u30fc\u30c8\u3092\u8981\u6c42\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n <\/div>\n\n<\/div>","protected":false},"excerpt":{"rendered":"

      \u30b0\u30e9\u30d6\u30ea\u30b8\u30f3\u306f\u3001\u5b9f\u9a13\u5ba4\u3067\u306e\u30c7\u30fc\u30bf\u304c\u305d\u306e\u5f8c\u306e\u958b\u767a\u4f5c\u696d\u3088\u308a\u3082\u5358\u7d14\u306b\u898b\u3048\u308b\u3053\u3068\u304c\u3042\u308b\u5316\u7ca7\u54c1\u6709\u52b9\u6210\u5206\u306e\u4e00\u3064\u3067\u3059\u3002\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u963b\u5bb3\u306f\u901a\u5e38\u3001\u2026<\/p>","protected":false},"author":1,"featured_media":15483,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[357],"tags":[],"class_list":["post-15482","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-product-updates"],"yoast_head":"\nGlabridin and Melanogenesis: Understanding Its Role in Pigment Biology - Natural huatai<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.natural-huatai.com\/ja\/glabridin-and-melanogenesis-understanding-its-role-in-pigment-biology\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Glabridin and Melanogenesis: Understanding Its Role in Pigment Biology\" \/>\n<meta property=\"og:description\" content=\"Glabridin is one of those cosmetic actives where laboratory data can look more straightforward than the development work that follows. 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